Assessment of Early Nephrotoxicity of Low-Dose Melamine in Wistar Albino Rats Using Conventional and Novel Biomarkers

• Publish Date: 2 - November - 2025

Research Abstract:

This study aimed to assess the renal toxicity of low-dose melamine (8 and 16 mg/kg bw/day) in male Wistar Albino rats over multiple exposure periods. Conventional markers (creatinine and urea) showed no significant changes, except for a significant decrease in estimated glomerular filtration rate (eGFR) in the higher dose group after 4 weeks. Importantly, early biomarkers (NGAL, RBP, and α1-M) revealed dose- and duration-dependent renal injury, with clear changes appearing as early as week three at the higher dose. These findings highlight the sensitivity of early biomarkers in detecting renal injury at low melamine doses, underscoring the need to reconsider safe exposure limits and incorporate these markers into toxicity assessment protocols.

Publishers:

Mudar Sadiq

Mudar Sadiq