Dr. Wassim Abdel Wahed
PhD in Pharmaceutics and Pharmaceutical Technology, University of Lyon 1 – France, 2006.
Contact
- Wassimabdelwahed@alepuniv.edu.sy
Experiences:
Professional Experience
- Dean, Faculty of Pharmacy – University of Aleppo (2023–2025)
- Vice Dean for Scientific Affairs, Faculty of Pharmacy – University of Aleppo (2012–2021)
- Head of Department of Pharmaceutics and Pharmaceutical Technology – University of Aleppo (2015–Present)
- Academic Institutions
- University of Aleppo
- Ebla University
Researches:
QUALITATIVE PHYTOCHEMICAL SCREENING, ANTIOXIDANT AND WOUND HEALING ACTIVITIES OF PISTACIA PALAESTINA BOISS. EXTRACTS
This study aimed to perform a qualitative phytochemical screening of different parts of Pistacia palaestina and evaluate its antioxidant and wound healing activities for therapeutic applications. The results revealed the presence of important bioactive compounds such as phenols, tannins, flavonoids, saponins, terpenoids, and resins, while alkaloids and coumarins were absent. High total phenolic and flavonoid contents were detected, particularly in methanolic leaf and fruit extracts, which also demonstrated strong antioxidant activity. Furthermore, ointments prepared from these extracts significantly accelerated wound healing in experimental animal models compared to control and standard treatment groups. These findings suggest that Pistacia palaestina could serve as a promising natural source for skin wound treatment and future therapeutic applications. - Bulletin of Pharmaceutical Sciences.
3 - June - 2023
Read More >>Green synthesis of silver nanoparticles using Pistacia palaestina (Boiss). extract: Evaluation of in vivo wound healing activity
Plant extracts, rich in bioactive compounds such as phenolics and flavonoids, serve as reducing and stabilizing agents in nanoparticles fabrication. The Pistacia genus, comprising species like P. atlantica, P. lentiscus, and P. vera, has demonstrated significant potential in synthesizing metallic nanoparticles with enhanced physicochemical and biomedical properties. This review provides a comprehensive description of the phytochemical composition of different Pistacia species and their utilization in nanoparticles synthesis. It further explores the biological mechanisms underlying their antimicrobial, antioxidant, antiinflammatory, and anticancer activities, along with their safety and stability profiles. The review highlights the promise of Pistacia-derived metallic nanoparticles in biomedical applications, while emphasizing mechanistic, toxicological, and stability considerations crucial for clinical translation. - Journal of Research in Pharmacy
2 - January - 2023
Read More >>Green synthesis of silver nanoparticles using aqueous extract of Acacia cyanophylla and its antibacterial activity
This study aimed to synthesize silver nanoparticles through a green synthesis approach using Acacia cyanophylla extract as an eco-friendly, cost-effective, and efficient reducing agent, while evaluating the effects of preparation conditions on nanoparticle size and antibacterial activity. Silver nanoparticles were synthesized using aqueous silver nitrate and plant extract, and characterized by visual inspection, UV–Vis spectroscopy, dynamic light scattering (DLS), and scanning electron microscopy (SEM). The results confirmed the formation of silver nanoparticles by the appearance of a yellowish-brown color and an absorption peak at 460 nm, with an average particle size of 88.11 nm. The optimal synthesis conditions were achieved using aqueous extract at a 9:1 ratio (silver nitrate: extract), at 35°C for 48 hours, with stability maintained for up to 15 days at 5°C. Furthermore, the synthesized nanoparticles demonstrated strong antibacterial activity against Escherichia coli infection, with MIC values ranging from 3.125 to 12.5 μg/mL. These findings indicate that Acacia cyanophylla extract is an effective reducing agent for the preparation of stable silver nanoparticles with potent antibacterial properties. - Asparagus magazine
16 - September - 2021
Read More >>EVALUATION OF ANTIBACTERIAL ACTIVITY OF SOME MEDICINAL PLANTS BY BIOAUTOGRAPHY
This study aimed to qualitatively identify the bioactive compounds in Acacia cyanophylla, Phlomis syriaca, and Scolymus hispanicus using Thin Layer Chromatography (TLC), and to evaluate their antibacterial activity against Escherichia coli infection isolates. The results confirmed the presence of flavonoids, saponins, bitter principles, and essential oils in all three plants. Both aqueous and ethanolic extracts exhibited antibacterial activity, with the ethanolic extract of Acacia cyanophylla showing the strongest effect, reflected by the lowest MIC values. Bioautography analysis indicated that flavonoids were the main compounds responsible for the antibacterial activity. These findings suggest that Acacia cyanophylla is a promising natural source of antibacterial agents and may contribute to the development of plant-based therapeutic applications in the future. - مجلة الصيدلة العالمية
2 - September - 2021
Read More >>Green Synthesis of Silver Nanoparticles Using Acacia cyanophylla and Its Antibacterial Activity
Aims: The aim of this research is to conduct green synthesis of silver nanoparticles in an eco-friendly, economical and more effective approach using Acacia cyanophylla plant extract as well as to study the effects of the preparation conditions on the size of synthesized nanoparticles and its antibacterial activity. Methodology: In this study, silver nanoparticles have been synthesized by reduction method using aqueous silver nitrate solution and aqueous extract of Acacia cyanophylla. Then, their characterization has been studied by several methods, such as visual inspection, UV–Vis spectroscopy, dynamic light scattering and scanning electron microscope. In addition, the effects of (silver nitrate: extract) ratio, type extract, temperature and reaction time have been studied on the size of prepared silver nanoparticles. Furthermore, the antibacterial effect of these nanoparticles was studied on Escherichia coli using micro-dilution method and determination the Minimum Inhibitory Concentration (MIC). Results: The results showed that the silver nanoparticles prepared using Acacia cyanophylla extract have reported visible yellowish brown color formation and the absorption peak at 460 nm indicated the biosynthesis of silver nanoparticles. Moreover, they have average diameter (88.11) nm and the polydispersity index (PdI) was suitable. The optimal conditions for synthesis silver nanoparticles were using aqueous extract in 9:1 ratio (silver nitrate: extract) at 35 C for 48 h. These silver nanoparticles were stable in the in the fridge at 5 C for a maximum period of 15 days. On the other hand, the antibacterial tests showed that these nanoparticles have high antibacterial activity where the MIC value ranged between (3.125–12.5) μg/ml on E. coli isolates. Conclusion: We conclude that Acacia cyanophylla extract is considered effective as a reducing agent for the preparation of stable silver nanoparticles in certain conditions and this silver nanoparticle has a high antibacterial activity. - Asparagus magazine
7 - January - 2021
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