NSAIDs, glucocorticoids, aminosalicylates, and immunosuppressants are nowadays the most commonly used anti-inflammatory medicines, although they have cosiderable side effects. Nanoparticles (NPs), notably metallic NPs, have gained appeal in the development of safer anti-inflammatory drugs. Because conventional NP synthesis methods are limited by environmentally unfriendly chemicals and high energy consumption, alternative green synthesis of metallic and metal oxide NPs, including plant-mediated synthesis, has piqued the interest of researchers due to phytochemicals that can reduce metal precursors and stabilize the generated NPs. This method is an eco-friendly, non-toxic, and cost-effective. This review aimed to highlight studies concerningthe anti- inflammatory activity of different plant-mediated green synthesis of metal and metal oxide nanoparticles with anti-inflammatory properties covering papers since 2017. According to the findings, the majority of the NPs tested were AgNPs. Noticeably, few investigations were conducted to assess the stability and safety of these NPs. Remarkably, someNPs exert more anti-inflammatory activity than plant extract itself and the standard. Some anti-inflammatory tests were limited to in vitro testing. Obviously, there is a lack of information regarding the safety issues of these NPs and the determination of their active doses. Thus, further invitro and invivo pharmacological and toxicological studiesare required for these metal and metal oxide NPs to identify medicinal uses and avoid unintended adverse consequences. It is also urgent to test the stability of these NPs in various dosage forms after determining the optimal active dose

1 - May - 2024

This review article discusses the anti-inflammatory properties and safety of green-synthesized metal and metal oxide nanoparticles produced using plant-mediated methods. The study highlights green synthesis as an eco-friendly and safer alternative to conventional chemical nanoparticle synthesis methods. In this approach, natural phytochemicals from plant extracts are used to reduce and stabilize metallic nanoparticles. The review covers several types of nanoparticles, including: Silver nanoparticles (AgNPs) Gold nanoparticles Zinc oxide nanoparticles Iron oxide nanoparticles Cerium oxide nanoparticles The article explains their ability to: Inhibit pro-inflammatory cytokines Reduce oxidative stress Enhance anti-inflammatory therapeutic activity Minimize side effects compared with traditional anti-inflammatory drugs. The study also addresses safety and toxicological concerns, indicating that some nanoparticles may induce cellular toxicity at high concentrations. Therefore, the authors emphasize the need for further in vivo pharmacological and toxicological studies before these nanoparticles can

1 - May - 2024