Anti-Arthritis and Biosafety Properties of Green Synthesized Zinc Oxide Nanoparticles Loaded with Cedrus libani Extract

This study explored a safe and environmentally friendly method for synthesizing zinc oxide nanoparticles from Lebanese rice ethanolic extract and its aqueous fraction, with the aim of improving their efficacy and safety as promising preclinical candidates for arthritis treatment. The nanoparticles were characterized using several analytical techniques, and the results showed that both extracts successfully produced nanoparticles with small sizes and suitable physicochemical properties. The in vitro, ex vivo, and in vivo results demonstrated that the prepared nanoparticles had stronger anti-arthritic activity than the original plant extracts and sodium diclofenac in some tests, along with high permeability and a clear effect in reducing edema and inflammation. Safety tests also showed no acute or subacute toxic effects, confirming that these nanoparticles represent a promising natural and safe option for developing future arthritis therapies - المجلة الدولية للطب النانوي

20 - September - 2025