Direct spectrophotometric determination of sildenafil citrate in pharmaceutical preparations via complex formation with two sulphonphthalein acid dyes

• Publish Date: 1 - April - 2017

Research Abstract:

The produced (NO) activates the enzyme guanylate cyclase, which results in increased levels of cGMP, producing smooth muscle relaxation of the penile in the corpus cavernous and therefore having the potential to improve penile erectile function by allowing inflow of blood [13]. In methods A and B, dichloromethane was best suited for the preparation of BCG and BTB solutions. the DMSO solvent was found to be the ideal solvent to dissolve SIL, the effect of the diluting solvent was studied for two methods and the results showed that none of the solvents except dichloromethane formed sensitive and stable colored species in methods (A and B).[...] dichloromethane was used for dilution throughout the investigation. The proposed methods are advantageous over many of the reported spectrophotometric methods, Table4, due to their sensitivity, high molar absorptivity value (2.28 x 104 L. mol-1. cm-1 and 3.05 x104 L …

Publishers:

Shaza Affas